These are supplements I believe nearly everyone can take safely, with well-studied benefits.
This is not medical advice — do your own research and consult a healthcare professional.
See the recommended brands in the FAQ.
⏰ Timing Summary
Morning: Creatine, Omega-3 (first dose)
Evening: Omega-3 (second dose), Magnesium Glycinate, Glycine (~1 hr before bed), Melatonin (at bedtime)
NAC: Trial at night first. If it causes wakefulness, move to daytime. Can have paradoxical stimulating effects in some people.
🔴 Overrated: Skip These
Popular supplements that are either expensive wastes of money, carry real
health risks, or both. Save your cash.
Methylene Blue
Heavily promoted by biohackers as a nootropic and mitochondrial booster. The reality: nearly all cognitive claims come from cell and animal studies. Human evidence is preliminary, inconsistent, and often funded by interested parties. Methylene blue is an FDA-approved prescription drug for methemoglobinemia — not a supplement. "Supplement" versions are unregulated, vary wildly in purity, and may contain industrial contaminants. It also carries serious risks: serotonin syndrome if combined with SSRIs/SNRIs, and hemolytic anemia in people with G6PD deficiency. The hype far outpaces the science.
BCAAs (Branched-Chain Amino Acids)
If you eat enough protein (0.7+ g per lb of body weight), BCAAs are redundant. Your body needs all essential amino acids to build muscle — not just three of them. Complete protein sources (meat, eggs, whey, soy) already contain BCAAs in the right ratios. Supplementing BCAAs on top of adequate protein intake shows no additional benefit for muscle growth or recovery in controlled studies. Typically $25–40/month for expensive flavored water.
Glutathione (oral)
We recommend NAC + glycine on this site specifically because oral glutathione doesn't work well. Your digestive system breaks most of it down before absorption. Despite premium pricing ($30–60/month), oral glutathione supplements have poor bioavailability. The far cheaper and more effective approach is to give your body the precursors (NAC + glycine) and let it produce glutathione endogenously. Liposomal forms show slightly better absorption but cost 5–10x more than the precursors for marginal benefit.
Biotin
Massively marketed for hair and nail growth, but unless you have a diagnosed biotin deficiency (which is rare), supplementation does nothing. Most people get plenty from food. Worse, high-dose biotin can interfere with lab test results — including thyroid and cardiac panels — leading to false readings your doctor may not think to ask about. Cheap per pill, but the real cost is a misdiagnosis from skewed bloodwork.